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CASE REPORT
Year : 2017  |  Volume : 1  |  Issue : 2  |  Page : 81-83

Cancerous tonsillar hypertrophy caused by human papilloma virus


Department of ENT and Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Puducherry, India

Correspondence Address:
Satvinder Singh Bakshi
Department of ENT and Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Puducherry
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijofb.ijofb_18_17

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Human papillomavirus (HPV) is associated with the development of most anogenital carcinomas, including cervical cancer and has more recently been suggested to be a risk factor for a subset of head and neck squamous cell carcinoma. The prevalence of HPV in normal oral mucosa ranges from 0.6% to 81%. A 15-year-old female presented with complaints of chronically progressive pain on swallowing since 3 years. Examination revealed bilateral Grade III tonsillar enlargement with multiple warty appearances over the surface of the tonsils. Subsequently, she underwent tonsillectomy, and histopathologic study revealed tonsillar crypts lined by stratified squamous epithelium with focal koilocytic changes. PCR study detected HPV 11 DNA. The presence of HPV in the oral cavity and upper respiratory tract mucosa is of great importance since several studies have demonstrated an association of HPV with a great variety of benign and malignant lesions. The easy access to the tonsillar crypts and the favorable microenvironmental factors of the crypts may be causes of the high prevalence of HPV in nongenital regions. A rare case of benign papillomatosis of the tonsil is presented. The need for a long-term follow-up is highlighted to study the possibility and risk factors for malignant transformation.


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